An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors
نویسندگان
چکیده
منابع مشابه
Non-traditional functions of ubiquitin and ubiquitin-binding proteins.
Until recently, proteasome-mediated proteolysis dominated discussion about the function of ubiquitin, a highly conserved 76-amino acid polypeptide. However, a spate of new discoveries has opened up research into the functions of ubiquitin in regulating proteins by proteasome-independent processes. These investigations have led to a deeper understanding of the different types of ubiquitin modifi...
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Ubiquitylation is used to target proteins into a large number of different biological processes including proteasomal degradation, endocytosis, virus budding, and vacuolar protein sorting (Vps). Ubiquitylated proteins are typically recognized using one of several different conserved ubiquitin binding modules. Here, we report the crystal structure and ubiquitin binding properties of one such mod...
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The covalent modification of proteins by ubiquitination is a major regulatory mechanism of protein degradation and quality control, endocytosis, vesicular trafficking, cell-cycle control, stress response, DNA repair, growth-factor signalling, transcription, gene silencing and other areas of biology. A class of specific ubiquitin-binding domains mediates most of the effects of protein ubiquitina...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2016
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2016.09.010